Elsevier

Fertility and Sterility

Volume 116, Issue 6, December 2021, Pages 1432-1435
Fertility and Sterility

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Defining recurrent implantation failure: a profusion of confusion or simply an illusion?

https://doi.org/10.1016/j.fertnstert.2021.10.023Get rights and content
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Recurrent implantation failure (RIF) is a poorly defined clinical scenario marked by failure to achieve pregnancy after multiple embryo transfers. The causes and definitions of implantation failure are heterogeneous, posing limitations on study design as well as the interpretation and application of findings. Recent studies suggest a novel, personalized approach to defining RIF. Here, we review the implantation physiology and definitions of the implantation rate, failure, and RIF.

Key Words

ART
definition
embryo implantation
recurrent implantation failure

Cited by (0)

A.S.G. has nothing to disclose. S.L.Y. has nothing to disclose.

The authors acknowledge the support of The Eunice Kennedy Shriver National Institute for Child Health and Development (NICHD), Grant P01HD106485.