Elsevier

Fertility and Sterility

Volume 95, Issue 3, 1 March 2011, Pages 922-927
Fertility and Sterility

Infertility
Latent celiac disease in reproductive performance of women

https://doi.org/10.1016/j.fertnstert.2010.11.005Get rights and content
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Objective

To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance.

Design

Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery.

Setting

Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi.

Patient(s)

Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases).

Intervention(s)

None.

Main Outcome Measure(s)

The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy.

Result(s)

The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects.

Conclusion(s)

Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.

Key Words

Infertility
latent celiac disease
poor reproductive performance
pregnancy
serologic marker

Cited by (0)

A.K. has nothing to disclose. M.M. has nothing to disclose. N.B. has nothing to disclose. N.K. has nothing to disclose. R.K.G. has nothing to disclose. S.A. has nothing to disclose. S.P. has nothing to disclose. S.B. has nothing to disclose.

Supported by the Indian Council of Medical Research, New Delhi.