In vitro genotoxicity testing–Can the performance be enhanced?
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Keywords
Genotoxicity
In vitro mammalian cell test
Safety assessment
Alternative methods
Abbreviations
Carc
carcinogenicity
CAvit
in vitro chromosomal aberration test
CAviv
in vivo chromosomal aberration test
DB
database
DNAviv
in vivo DNA strand breakage (e.g. comet or alkaline elution) assay
EURL ECVAM
EU Reference Laboratory for Alternatives to Animal Testing
GFP
green fluorescence protein
HET-MN
Henn's egg test for micronucleus induction
Hprt
hypoxanthine-guanine phosphoribosyl transferase locus
IATA
integrated approach to testing and assessment
MLA/tk
mouse lymphoma tk gene mutation assay
MNvit
in vitro micronucleus test
MNviv
in vivo micronucleus test
NTP
National Toxicology Program
OECD
Organisation for Economic Co-operation and Development
PPP
plant protection products
SCCS
Scientific Committee on Consumer Safety
TG
Test Guideline
TGR
in vivo transgenic rodent mutation assay
UDSviv
in vivo unscheduled DNA synthesis test
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© 2016 European Commission Joint Research Centre. Published by Elsevier Ltd.