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Validity of the Geriatric Depression Scale-30 against the gold standard diagnosis of depression in older age: The GreatAGE Study

Published online by Cambridge University Press:  23 March 2020

M. Lozupone ,
F. Veneziani ,
I. Galizia ,
L. Lofano ,
D. Montalbò ,
S. Arcuti ,
R. Tortelli ,
M.R. Barulli ,
R. Capozzo  and
C. Bonfiglio
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M. Lozupone*
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
F. Veneziani
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
I. Galizia
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
L. Lofano
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
D. Montalbò
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
S. Arcuti
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
R. Tortelli
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
M.R. Barulli
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
R. Capozzo
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
C. Bonfiglio
Affiliation:
IRCCS “S. De Bellis”, Epidemiology and Biostatistics Laboratory, Castellana Grotte BA, Italy
F. Panza
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
D. Seripa
Affiliation:
Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo FG, Italy
O. Todarello
Affiliation:
Psychiatric Unit, Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
G. Logroscino
Affiliation:
Pia Fondazione “Cardinale G. Panico”, Tricase, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Tricase LE, Italy
*
*Corresponding author.

Abstract

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Introduction

Depression is a common disorder in late-life. Structured clinical interviews may be less efficient compared to self-administered questionnaires, but provide more accurate findings in terms of diagnosis. No population-based studies with both these depression assessment instruments have been ever performed.

Objectives

To estimate the GDS-30 accuracy for depression assessment against the gold standard [Semi-structured Clinical Diagnostic Interview for DSM-IV-TR Axis I Disorders (SCID)] in subjects 65+ years in a random sampling of the general population.

Methods

The sample was collected in a population-based study (GreatAGE) conducted among elderly residents in Castellana, Southeast Italy. It includes 597 participants (57.62% males, mean age 73 years). Depression was assessed through the GDS-30 and the SCID, both double-blinded administered respectively by a trained neuropsychologist and psychiatrist. The GDS-30 screening performances were analyzed using ROC curves.

Results

According to the gold standard SCID, the rate of depressive disorder was 10.22% (15.81% of women; 6.1% of men) while with GDS-30 instrument 12.06% of the residents met the depression cutoff. Only 36.1% of GDS cases were true positive. At the optimal cutoff score (> 5), GDS had 62% sensitivity and 81% specificity. Using a more conservative cutoff (> 9), the GDS-30 specificity reached 91% while sensitivity dropped to 43%.

Conclusions

These preliminary results from the first population-based study that compares GDS-30 and SCID showed that the GDS-30 identified adequate levels of screening accuracy (AUC 0.76) compatible with scores established in community settings.

Funding

PRIN2009E4RM4Z.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
FC38
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S85
Copyright
Copyright © European Psychiatric Association 2016
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