This article presents the design of an Adaptive Neuro-Fuzzy Inference Controller (ANFIC) for a 160 MW power plant. The space of operating conditions of the plant is partitioned into five regions. For each of the regions, an optimal controller is designed to meet a set of design objectives. The resulting five linear controllers are used to train the ANFIC. To enhance the applicability of the control system, a new algorithm that reduces the fuzzy rules to the most essential ones is also presented. This algorithm offers substantial savings in computation time while maintaining the performance and robustness of the original controller.