doi:10.1016/j.endeavour.2008.07.001
Copyright © 2008 Elsevier Ltd All rights reserved.
Feature
East meets West: how China almost cured malaria
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William R. Burnsa,
, 
aDiamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia
Available online 8 August 2008.
With the isolation of quinine from Cinchona in 1820, an ancient herbal cure was transformed into a chemical drug. This was the inspiration for a new scientific discipline – ethnopharmacology – as Western scientists began to reinvent traditional herbal cures by extracting their active principles to make new and profitable drugs. The Chinese government may claim many such success stories as their own, but such triumphant narratives only reveal part of the story. The drawn-out hunt for the active principle of another anti-malarial herb, changshan, or Dichroa febrifuga, offers a more nuanced narrative that captures the complex interplay between traditional Chinese and Western medicine.
Figure 1. Dichroa febrifuga. Reproduced from Bouillat (op. cit. p. 20).
Figure 2. Price of one kilogram of quinine sulphate in France 1880–1926. Reproduced from Perrot (op. cit. p. 159).
Figure 3. Anatomical drawings of Dichroa febrifuga. Reproduced from Bouillat (op. cit. pp. 22–23).
Figure 4. Bouillat injected an extract of the leaves of Dichroa febrifuga into a dog and measured the pressure in the carotid artery after paralysing the vagal nerve with atropine. The first white cross marks the injection of 1.25 g D. febrifuga extract. The second white cross marks the injection of 3.75 g extract leading to a ‘sudden and terminal fall in the arterial pressure’ that killed the dog. The bottom trace records the time in seconds. Reproduced from Bouillat (op. cit. p. 55).
Figure 5. The site of Zhang Changshao's laboratory outside Chongqing, photographed by Joseph Needham during the Second World War. Reproduced from Needham, J. (1945) Chinese Science, Pilot Press, p. 29. Courtesy of the Needham Research Institute.