Cooperation is an approach of improving competitive advantages of a supply chain. A two-echelon supply chain consisting of a manufacturer and a retailer for a single-period product is studied, and retail-market demand uncertainty is described by coefficient of variation. We develop a cooperation mechanism to address the cooperation and its implementation between the manufacturer and the retailer, two market situations are considered: (i) the wholesale price and the order quantity are decision variables, (ii) the wholesale and the retail prices as well as the order quantity are decision variables. In both market situations, our research shows that: (1) the cooperation mechanism can improve the overall channel profits and the supply chain members’ allocated profits, (2) the described cooperation is conditional on retail-market demand uncertainty: it can be implemented if, and only if, the fluctuation of retail-market demand is relatively small and coefficient of variation of retail-market demand does not exceed an upper bound. Impacts of retail-market demand uncertainty on wholesale price, order quantity and/or retail price have also been investigated through analytical and numerical analyses. Although our research is based on the assumption that the manufacturer dominates the supply chain in the non-cooperative situation, which is not the case for most retailer-driven supply chains, this research is still significant on providing guidelines for practitioners in current China mid-level car market that is similar to situations described in the paper.