Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling

Highlights

• HDAC6 regulates the cytoskeletal assembly.

• The interplay of HDAC6 ZnF UBP is crucial for various cellular activities.

• The function of HDAC6 is highly complex with respect to Taoupathies in AD.

Abstract

Cytoskeletal elements are the key players in cellular integrity, structure, signalling and migration. Each cytoskeletal element comprises of properties with respect to its structure and stability, which serve a specific array of functions. These structures are highly dynamic and regulated by modulation via direct interaction or post-translational modifications. HDAC6 is a cytoplasmic deacetylase known to regulate a wide range of cellular functions either through its deacetylase activity or direct interaction via its C-terminal ZnF UBP domain. HDAC6 has been widely studied for its role in aggresome formation, which acts as a protective mechanism upon protein aggregation. HDAC6 is known to play a critical role in the regulation of cytoskeletal elements-microtubules and actin filaments. This review summarizes the regulatory role of HDAC6 in cytoskeletal remodeling and dynamics of neuronal cells and its significance in neurodegenerative diseases.