Journal of the American Society of Echocardiography
Original articlePrediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction: Comparison with Contrast-enhanced Magnetic Resonance Imaging
Section snippets
Study Population
Thirty consecutive patients who underwent successful percutaneous coronary intervention (PCI) within 48 hours of symptom onset for AMI were included in the study. After PCI all the patients were given a daily dose of aspirin (100 mg) and clopidogrel (75 mg) for at least 3 months. The exclusion criteria were as follows: (1) history of myocardial infarction; (2) absence of thrombolysis in myocardial infarction grade 3 coronary flow in the infarct-related artery after PCI; (3) additional clinical
Reproducibility of Data
Interobserver variability for measuring relative CI, A × β in MCE, and percentage DE in ceMRI was 12.3%, 10.7%, and 4.1%, respectively. Intraobserver variability was 9.2%, 8.3%, and 2.7%, respectively.
Patient Characteristics
Of the 30 patients (mean age 59.2 ± 10.7 years), 25 (83%) were male and 5 (17%) were female. In all, 24 patients had left anterior descending coronary artery (LAD)-, two had left circumflex coronary artery (LCx)-, and 4 had right coronary artery (RCA)-territory myocardial infarction. A total of 25
Discussion
Using the myocardial contrast replenishment curve and the new method of measuring the relative CI (pixel-by-pixel method), we could successfully obtain the index of MBF and absolute MBVF. Our results demonstrate that MCE-derived A × β and MBVF can be effective predictors of the TEI and later wall-motion improvement in patients with reperfused AMI with acceptable sensitivity and specificity.
References (24)
- et al.
Myocardial contrast echocardiography with a new calibration method can estimate myocardial viability in patients with myocardial infarction
J Am Coll Cardiol
(2004) - et al.
The quantification of absolute myocardial perfusion in humans by contrast echocardiography
J Am Coll Cardiol
(2005) - et al.
Quantification of myocardial perfusion and determination of coronary stenosis severity during hyperemia using real-time myocardial contrast echocardiography
J Am Soc Echocardiogr
(2001) - et al.
The basis for stenosis detection using venous administration of microbubbles during myocardial contrast echocardiographyBolus of continuous infusion?
J Am Coll Cardiol
(1998) - et al.
Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization
J Am Coll Cardiol
(1998) - et al.
Early changes in myocardial perfusion patterns after myocardial infarction: relation with contractile reserve and functional recovery
J Am Coll Cardiol
(1998) - et al.
Myocardial contrast echocardiography versus dobutamine echocardiography for predicting functional recovery after acute myocardial infarction treated with primary coronary angioplasty
J Am Coll Cardiol
(1996) - et al.
Intravenous myocardial contrast echocardiography predicts recovery of dyssynergic myocardium early after acute myocardial infarction
J Am Coll Cardiol
(2001) - et al.
Microvasculature in acute myocardial ischemia, part II: evolving concepts in pathophysiology, diagnosis, and treatment
Circulation
(2003) - et al.
Noninvasive imaging of myocardial viability: current techniques and future development
Circ Res
(2003)
Relationship of MRI delayed contrast enhancement to irreversible injury, infracted age, and contractile function
Circulation
Evaluation of myocardial viability with contrast echocardiography
Am J Cardiol
Cited by (15)
Functional Recovery After Acute Myocardial Infarction. Comparison Between Angiography, Electrocardiography, and Cardiovascular Magnetic Resonance Measures of Microvascular Injury
2008, Journal of the American College of CardiologyContrast Echocardiography: Evidence for Clinical Use
2008, Journal of the American Society of EchocardiographyCitation Excerpt :MCE may also play a pivotal role in the prediction of functional recovery in patients after ST-segment-elevation myocardial infarction by visualizing reflow of blood to the area at risk. The ability of MCE to predict functional recovery is comparable with that of cardiovascular magnetic resonance imaging.73,74 MCE has been shown to provide greater accuracy than SPECT in the assessment of myocardial viability in patients after acute myocardial infarction.75,76
The clinical applications of myocardial contrast echocardiography
2007, European Journal of EchocardiographyRole of coronary microcirculation in no-reflow phenomenon in myocardial infarction with ST segment elevation
2019, Microcirculation: From Bench to Bedside
Supported by Yonsei University College of Medicine Research Fund of 2005.