Elsevier

EBioMedicine

Volume 13, November 2016, Pages 274-283
EBioMedicine

Research Paper
Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

https://doi.org/10.1016/j.ebiom.2016.10.020Get rights and content
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Highlights

  • Renal sinus adipose tissue accumulation is asymmetric

  • KIM (kidney injury molecule)-1 level is positively associated with renal sinus adipose tissue amount

  • FGF (fibroblast growth factor)-21 level is associated with renal sinus and retroperitoneal adipose tissue amount

Obesity is a common contributing factor to the development of chronic kidney disease, hypertension, and predispose to the calcium oxalate and urate stones. The distribution of adipose tissue between different depots seems to be more important than the total adipose tissue mass for the risk of developing obesity-associated diseases. This research is dedicated to the renal sinus adipose tissue. The article reveals that renal sinus adipose tissue deposition is asymmetric–the left compared to the right renal sinus accumulates significantly higher adipose tissue amount. Additionally, there is association between renal sinus adipose tissue increase and proximal tubule epithelial cells damage.

Abstract

Objective

A potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS). The aim of the study was to quantify RS and abdominal adipose tissue volumes and to evaluate serum kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21 association with different adipose tissue compartments.

Methods

The cross-sectional study included 280 and follow-up study-40 asymptomatic participants; aged 38.30 ± 4.10. For all study participants computed tomography examination was performed, sKIM-1 and FGF-21 levels were measured.

Results

The results indicated asymmetrical deposition of adipose tissue into the RS even after corresponding kidney volume adjustment. The cross-sectional and the follow-up studies showed that sKIM-1 level was positively associated with RS adipose tissue volume increase for both genders. FGF-21 was positively associated with RS and retroperitoneal adipose tissue amount.

Conclusions

Regardless of gender adipose tissue in RS accumulates asymmetrically–the left RS accumulates a significantly higher amount of adipose tissue. Thus, primarily RS adipose tissue effects should be assessed on the left kidney. Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 and FGF-21 concentration increase in the blood serum.

Keywords

Asymmetry
Renal sinus
KIM-1
FGF-21
Obesity
Visceral adipose tissue

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