Elsevier

Data in Brief

Volume 7, June 2016, Pages 1204-1210
Data in Brief

Data Article
Characterization data on the topical carrier DDC642

https://doi.org/10.1016/j.dib.2016.03.091Get rights and content
Under a Creative Commons license
open access

Abstract

This article contains original data, figures and methods used in the characterization of the liposomal carrier ‘DDC642’ for topical applications, described in “An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis” (Desmet et al., 2016) [1]. Several elastic liposomal formulations have been evaluated for their ability to encapsulate and deliver RNA interference (RNAi) molecules to cultured primary skin cells. The efficiency and effectiveness of these liposomes were compared to that of our previously characterized liposomes, the ‘SECosomes’ (SEC) (Geusens et al., 2010) [2]. After selection of a potential superior carrier, based on encapsulation and transfection efficiency data (Desmet et al., 2016) [1], the selected DDC642 liposomes were characterized more in-depth. Herein, a detailed characterization of the DDC642 liposome and RNAi-loaded lipoplexes is given, including the matching protocols.

Keywords

Gene therapy
Lipid-based nanoparticle
Liposome
RNA interference
Topical drug delivery

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1

Equal contribution.