Developmental Cell
Volume 22, Issue 6, 12 June 2012, Pages 1149-1162
ArticleCleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Participation in Fas-Induced Apoptosis
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Graphical Abstract
Highlights
► Deletion of TRPM7 in T cells reduces apoptosis in response to Fas stimulation ► TRPM7 is cleaved by caspases at D1510, dissociating the channel from the kinase ► The TRPM7 channel, but not the released kinase, participates in apoptotic signaling ► TRPM7 regulates Fas receptor internalization
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These authors contributed equally to this work
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Present address: Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
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