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RCM alone or in combination with dermoscopy or OCT has been shown to significantly improve accuracy in detection of tumor margins and recurrences in skin cancer.
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This tool can be useful in clinical trials and in clinical practice with this indication in melanocytic and nonmelanocytic tumors using either a handheld device or the standard RCM device to produce vivablocks.
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The main advantage of the first technical option is the reduced time of examination to a few minutes.
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It is probable that in the
The Role of Reflectance Confocal Microscopy in Clinical Trials for Tumor Monitoring
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Key points
Reflectance Confocal Microscopy in Actinic Keratosis
Evaluation of efficacy of treatment of actinic keratosis (AK) and field cancerization in clinical trials traditionally has been done with naked examination and biopsies of lesions. For clinical evaluation, clinical pictures for documentation of the tumor can also be used. However, the clinical naked eye examination cannot assess with accuracy tissue changes or the presence of subclinical lesions, whereas biopsies have the inconvenience of local scar, pain, and the lack of dynamic information
Summary
RCM alone or in combination with dermoscopy or OCT has been shown to significantly improve accuracy in detection of tumor margins and recurrences in skin cancer. This tool is useful in clinical trials and in clinical practice with this indication in melanocytic and nonmelanocytic tumors using either a handheld device or the standard RCM device to produce vivablocks. The main advantage of the first technical option is the reduced time of examination to a few minutes. In the future faster
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Reflectance confocal microscopy: Principles, basic terminology, clinical indications, limitations, and practical considerations
2021, Journal of the American Academy of DermatologyCitation Excerpt :While RCM-based margin mapping is currently limited to research studies in the United States, these results have been incorporated into evidence-based clinical practice guidelines for the management of LM in Australia.34 RCM is also under investigation in monitoring response to noninvasive therapies.35,36 Assessment of tumor clearance after treatment, based on clinical and dermoscopic examination, is limited because of hyperpigmentation and erythema at the treatment site.12
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