New Techniques in Articular Cartilage Imaging

To test whether T2 mapping of the sacro-iliac joints (SIJs) might help identifying patients with spondyloarthritis.

This study included 20 biologic-naive patients with axial spondyloarthritis (10 females; mean age: 38 ± 9years; range, 19–47) and 27 controls (16 males; mean age = 39 ± 13years; range = 28–71) who prospectively underwent SIJs MRI at 1.5 T, including a multislice multiecho spin-echo sequence. Standard MRIs were reviewed to assess the SIJs according to the Assessment of SpondyloArthritis International Society (ASAS) criteria and SPondyloArthritis Research Consortium of Canada (SPARCC) MRI index. T2 maps obtained from multiecho sequences were used to draw regions of interests in the cartilaginous part of the SIJs. Disease activity was assessed using BASDAI questionnaire. Bland-Altman method, ROC curve analysis, Chi square, Mann-Whitney U, Pearson’s and Spearman's correlation coefficient were used for data analysis.

According to ASAS criteria, MRI was positive for sacroiliitis in 5/20 patients (25 %). Inter-observer reproducibility of T2 values was 87 % (coefficient of repeatability = 7.0; bias = 0.49; p < .001). Mean T2 values of patients (58.5 ± 4.4 ms, range: 52.6–68.2 ms) were significantly higher (p < .001) than those of controls (44.1 ± 6.6 ms, range: 33.6–67.2 ms). A T2 value of 52.51 ms yielded 100 % sensitivity and 91.7 % specificity to differentiate patients from controls. No statistically significant association/correlation was found between T2 values and BASDAI (r=˗.026, p = .827), disease duration (r = .024, p = .871), SPARCC (r=-.004, p = .981), ASAS criteria (p = .476), HLA-B27-positivity (p = .139), age (r=-.2.53, p = .891), and gender (p = .404).

T2 relaxation times of the SIJs were significantly higher in patients than in healthy controls, making this tool potentially helpful to early identify patients with spondyloarthritis.

The purpose of this study was to analyze the association between the prevalence of meniscal and chondral lesions and the timing of surgery in patients undergoing primary anterior cruciate ligament (ACL) reconstruction to determine a safe time for surgery.

This retrospective study involved 226 patients (91 females and 135 males; median age, 29 years) undergoing primary ACL reconstruction. Time interval from ACL injury to surgery (median, 4 months; range, 1–420 months) and concomitant meniscal and cartilage lesions in ACL reconstruction were reviewed. Receiver operating characteristic (ROC) curve analysis was used to determine the precise threshold interval to surgery to prevent meniscal or cartilage lesions. The risk of lesion occurrence after each cutoff period was determined using odds ratio (OR).

The incidences of medial meniscus (MM), lateral meniscus (LM), and cartilage lesions were 43.8%, 32.7%, and 27.4%, respectively. ROC analysis revealed that patients who waited for more than 6, 4, and 5 months for ACL reconstruction had a significantly greater risk of associated MM, LM, and chondral lesions, respectively. Patients who underwent ACL reconstruction ≥7 months after injury had OR of 4.1 (p < 0.001) for the presence of MM lesion as compared with those who underwent reconstruction within 6 months. Similarly, patients who underwent ACL reconstruction ≥5 months after injury had OR of 1.9 (p = 0.023) for the presence of LM lesion as compared with those who underwent reconstruction within 4 months, and patients who underwent ACL reconstruction ≥6 months after injury had OR of 2.9 (p < 0.001) for chondral lesion as compared with those who underwent reconstruction within 6 months.

ACL reconstruction should be performed within approximately 6 months after the injury to prevent associated meniscal or chondral lesions.

To evaluate a delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index designed to predict focal acetabular articular cartilage damage in patients with femoroacetabular impingement (FAI).

The inclusion criteria were patients who underwent dGEMRIC and hip arthroscopy between April 2010 and August 2015 for FAI syndrome. The exclusion criteria were previous hip conditions, a Tönnis grade greater than 1, and a delay between magnetic resonance imaging and surgery greater than 180 days. The cutoff value for full-thickness chondral damage was set to 350 milliseconds. The coronal anterolateral (CAL) index was designed to evaluate focal articular anterolateral chondral defects. We calculated the binary classification test of the CAL index for full-thickness chondral damage, with arthroscopy as the gold standard. We calculated the correlation between the CAL index and the arthroscopically defined acetabular labrum articular disruption (ALAD) and Outerbridge grades and tested for differences between no or mild focal chondral damage and moderate or severe focal chondral damage. We repeated this analysis on the sagittal superior index, a combination of the sagittal anterior and posterior indices.

A total of 195 hips (183 patients) were reviewed. The CAL index showed a sensitivity of 55% (95% confidence interval [CI], 32%-76%), specificity of 81% (95% CI, 74%-86%), positive predictive value of 27% (95% CI, 18%-37%), and negative predictive value of 93% (95% CI, 90%-96%). The CAL index showed a significant difference between no or mild focal chondral damage and moderate or severe focal chondral damage per both ALAD and Outerbridge groups (P < .0001). The CAL index was moderately inversely correlated with ALAD and Outerbridge grades (ρ = –0.403, P < .0001). The sagittal superior index was not significantly different between the groups and showed a weak correlation with focal defects.

The CAL index may play a role in ruling out full-thickness articular cartilage defects in patients with FAI syndrome. In addition, it may help in differentiating between no or mild focal chondral damage and moderate or severe focal chondral damage.

Level III, case-control study.