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Computational Biology and Chemistry
Volume 31, Issue 1, February 2007, Pages 1-10
 
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doi:10.1016/j.compbiolchem.2006.09.005    How to Cite or Link Using DOI (Opens New Window)
Copyright © 2006 Elsevier Ltd All rights reserved.

An analysis of the Petri net based model of the human body iron homeostasis process

Andrea Sackmanna, b, Dorota Formanowiczc, Piotr Formanowicza, d, Corresponding Author Contact Information, E-mail The Corresponding Author, Ina Kochb and Jacek Blazewicza, d

aInstitute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan, Poland bBioinformatics Group, Technical University of Applied Sciences Berlin, Seestr. 64, 13347 Berlin, Germany cDepartment of Clinical Biochemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland dInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland

Received 11 August 2006; 
accepted 20 September 2006. 
Available online 9 November 2006.

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Abstract

In the paper a Petri net based model of the human body iron homeostasis is presented and analyzed. The body iron homeostasis is an important but not fully understood complex process. The modeling of the process presented in the paper is expressed in the language of Petri net theory. An application of this theory to the description of biological processes allows for very precise analysis of the resulting models. Here, such an analysis of the body iron homeostasis model from a mathematical point of view is given.

Keywords: Iron homeostasis; Metabolic pathways; Petri nets

Article Outline

1. Introduction
2. Human body iron homeostasis
3. Petri nets
3.1. Definitions
3.1.1. Petri net properties
3.2. Model development
3.3. Invariant analysis
4. Results and discussion
4.1. The model of the human body iron homeostasis
4.2. Analysis of the results
4.2.1. Structural analysis
4.2.2. Invariant analysis
5. Conclusions
Acknowledgements
References





 
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