Cell Metabolism
Volume 21, Issue 5, 5 May 2015, Pages 663-665
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Come to Where Insulin Resistance Is, Come to AMPK Country

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The link between smoking and insulin resistance, despite weight loss, is well established; however, the underlying mechanisms remain elusive. A recent article published in Nature Medicine by Wu et al. (2015) reports that nicotine, the main bioactive component of tobacco smoke, activates AMPKα2 in adipocytes, leading to impaired insulin sensitivity.

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