Cell Metabolism
Volume 6, Issue 4, 3 October 2007, Pages 254-256
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Estrogen and Bone: Osteoclasts Take Center Stage

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Loss of estrogen at menopause causes osteoporosis in many women, but estrogen's relevant cellular target in this process has remained unclear. In a recent study in Cell, Kato and colleagues (Nakamura et al., 2007) selectively ablate estrogen receptor α in osteoclasts and demonstrate that estrogen directly induces osteoclast apoptosis.

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