Changing paradigms in dermatology: tumor necrosis factor alpha (tnf-α) blockade in psoriasis and psoriatic arthritis
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Treatments for psoriasis: A journey from classical to advanced therapies. How far have we reached?
2022, European Journal of PharmacologyCitation Excerpt :In psoriatic skin, dermal macrophages, dendritic cells, T cells and keratinocytes are rich sources of TNFα (Schottelius et al., 2004). It is crucial in stimulating several cytokines, chemokines and adhesion molecules in psoriasis and other autoimmune disorders involving the Th1 cascade (Ogilvie et al., 2006; Victor et al., 2003). The efficacy of TNFα inhibitors is primarily due to their role in preventing the activation of dendritic cells, which produce IL23 and activation of Th17 lineage and its effector molecules (IL17 & IL22).
Potential effects and mechanisms of Chinese herbal medicine in the treatment of psoriasis
2022, Journal of EthnopharmacologyA brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis
2018, CytokineCitation Excerpt :Wang et al. determined that there are many infiltrated macrophages in the skin lesions and that these macrophages are an important source of TNF-α within the skin (Fig. 1). Therapeutic-based studies showed that using etanercept as a potent TNF-α signaling blocker drug could be an effective agent in the treatment of human PsO because it improved psoriasiform skin inflammation, reduced the numbers of macrophages in skin lesions, and decreased the production of TNF-α by macrophages [62,63]. To more precisely assess the involvement of macrophages, Wang et al. [60] used clodronate liposomes to deplete the macrophages from the skin lesions.
Integrative methylome and transcriptome analysis to dissect key biological pathways for psoriasis in Chinese Han population
2018, Journal of Dermatological ScienceCitation Excerpt :Activation of NF-κB in keratinocytes has been reported to result in the production of multiple immune-related proteins and leads to further inflammatory response [39,40]. In addition, NF-κB acts as a central mediator which links the activated Th1 cells with the transcription of multiple genes encoded cytokines, such as TNF-α, IL-8, and IL-12 that are required for the pathogenesis of Ps [41–43]. Morphologic and metabolic alterations in PN skin, including processes of lipid metabolism, predominantly in the horny layer of the skin, have been reported decades ago [44,45], characterized by changes in phospholipid composition and levels and distribution of several hydrolytic enzymes and dehydrogenases.
Serious infections among a large cohort of subjects with systemically treated psoriasis
2017, Journal of the American Academy of Dermatology