The Answer for Inhaled Antibiotics in Pneumonia Is Still Blowing in the Wind

doi:10.1016/j.chest.2016.11.034

Chest

Volume 151, Issue 6, June 2017, Pages 1201-1203

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Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study
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Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock
Crit Care Med
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Cited by (3)

Efficient degradation of ciprofloxacin by a flower-spherical Bi<inf>2</inf>MoO<inf>6</inf>/BiOCl Z-type heterojunction photocatalyst enriched with oxygen vacancies
2023, Journal of Environmental Chemical Engineering
Ciprofloxacin (CIP) is difficult to degrade naturally, for example by microorganisms, and will persist in water bodies for a long period of time, seriously jeopardizing the ecological environment and human health. Photocatalysis has high practical application value as a green and efficient technology. However, the photogenerated electrons and holes of the photocatalysts are prone to complexation, which limits the degradation efficiency of photocatalysis. Therefore, in this work, spherical Bi₂MoO₆/BiOCl (OVs-BMO/BOC) Z-type heterojunction photocatalysts enriched with oxygen vacancies (OVs) were successfully synthesized by a hydrothermal-calcination method. A series of characterizations showed that the OVs-BMO/BOC photocatalysts could perform Z-type charge transfer, which increased the visible light response range and improved the separation efficiency of photogenerated electrons and holes, thus improving the degradation efficiency of CIP. Under visible light, the removal efficiency of OVs-BMO/BOC composites for CIP could reach 97.40% at 120 min. It has a quasi-primary rate constant of 0.03008, which is 4.1, 3.48, and 2.19 times higher than that of monomeric BOC, BMO, and BMO/BOC, respectively. Meanwhile, the good stability of OVs-BMO/BOC was verified, and its degradation efficiency could still reach 87.80% after four cycles. Finally, electron spin resonance analysis and trapping experiments were carried out, which demonstrated that a large number of OVs were produced by the BMO/BOC composite photocatalyst generated by calcination, and also identified that the OVs-BMO/BOC produced active substances (•OH, h⁺, and •O₂⁻), which revealed the mechanism of degradation of CIP by the OVs-BMO/BOC. Our study provides a new way of thinking to achieve efficient elimination of antibiotics from wastewater.
The Unfulfilled Promise of Inhaled Therapy in Ventilator-Associated Infections: Where Do We Go from Here?
2022, Journal of Aerosol Medicine and Pulmonary Drug Delivery
How should aerosols be delivered during invasive mechanical ventilation?
2017, Respiratory Care

: FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST the following: A. F. S. has served as a speaker for, consultant to, or received research support from Achaogen, Actavis, Astellas, Astra Zeneca, Bayer, BMS, Cardeas, Cempra, Medicines Company, Melinta, Merck, Paratek, Pfizer, Roche, Shionogi, Spero, Tetraphase, and Theravance. M. D. Z. has received consulting fees and/or research funding from Achaogen, Astellas, The Medicines Company, Melinta, Merck, Pfizer, Shionogi, Tetraphase, and Theravance.

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Chest

EditorialThe Answer for Inhaled Antibiotics in Pneumonia Is Still Blowing in the Wind

Chest

International study of the prevalence and outcomes of infection in intensive care units

JAMA

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

BMC Infect Dis

Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study

Crit Care

Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock

Crit Care Med

Editorial
The Answer for Inhaled Antibiotics in Pneumonia Is Still Blowing in the Wind