ReviewEffects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma
Section snippets
Literature Search
Separate computer-assisted searches were performed using PubMed. Each search was performed on all English language articles through June 2008, using the exploded medical subject heading terms lymphoma, Helicobacter pylori, therapy, eradication, remission, and follow up. Boolean operators (NOT, AND, OR) also were used in succession to narrow and widen the search. Only studies concerning primary, low-grade, MALT lymphoma of the stomach associated with H pylori infection were considered; diffuse
Search Results
After a thorough review of the titles, abstracts, and text of the potentially relevant studies, the full text from 79 studies of H pylori eradication in patients with gastric lymphoma was retrieved and evaluated. Of these, 32 trials met inclusion criteria for this pooled analysis13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44; 47 studies were not included (Table 1). The exclusion criteria were as follows: (1)
Discussion
Primary gastric MALT lymphoma is a neoplasia that is associated with H pylori infection. H pylori eradication leads to complete remission of gastric low-grade lymphoma in 35% to 100% of patients, according to different studies.1 A recent systematic review described a high rate of remission (68.8% in 61 cases) in patients with high-grade lymphoma after therapy via only bacterial eradication.45 Current international guidelines suggest bacterial eradication therapy for all patients with MALT
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Conflicts of interest The authors disclose no conflicts.