A Review of New Developments in Tissue Engineering Therapy for Periodontitis

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Protein-based approaches

Growth and differentiation factors can regulate the adhesion, migration, proliferation, and differentiation of various types of cell by binding to appropriate receptors. Recent advances in genetic engineering technology have made it possible to obtain large quantities of human recombinant proteins. The use of growth and differentiation factors is the most popular tissue engineering approach for regenerating periodontal tissues. So far, several growth factors—including transforming growth

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    This work was supported by a Grant-in-Aid for Scientific Research 16791322 from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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    Published by Elsevier Inc.