Invited critical reviewGene methylation in gastric cancer
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Abbreviations
5-hmC
5-hydroxymethylcytosine
5-mC
5-methylcytosine
ADAM23
ADAM metallopeptidase domain 23
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
ARID1A
AT rich interactive domain 1A (SWI-like)
AML
Acute myelocytic leukemia
ATBF1
AT motif-binding factor 1
APC
Adenomatosis polyposis coli
BS
Bisulfite sequencing
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
BTG4
B-cell translocation gene 4
BMP-2
Bone morphogenetic protein 2
CACNA1G
Calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA2D3
Calcium channel, voltage-dependent, alpha 2/delta subunit 3
CD44
CD44 molecule (Indian blood group)
CDH1
Cadherin 1 or E-cadherin
CDK4
Cyclin-dependent kinase 4
CDK6
Cyclin-dependent kinase 6
CDKN1C
Cyclin-dependent kinase inhibitor 1C
CDKN2A
Cyclin-dependent kinase inhibitor 2A
CDX2
Caudal type homeobox 2
CHD5
Chromodomain helicase DNA binding protein 5
CHFR
Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CGI
CpG islands
C-MET
Met proto-oncogene (hepatocyte growth factor receptor)
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
CRBP1
Retinol binding protein 1, cellular
CNS
Central nervous system
DACT1
Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
DAPK
Death-associated protein kinase
Dkk-3
Dickkopf 3 homolog (Xenopus laevis)
DNA
Deoxyribose Nucleic Acid
DNMT
DNA methylatransferases
EBV
Epstein–Barr Virus
ECRG4
Chromosome 2 open reading frame 40
EDNRB
Endothelin receptor type B
EGCG
Epigallocatechin gallate
ERBB4
V-erb-a erythroblastic leukemia viral oncogene homolog 4
FDA
Food and Drug Administration
FLNc
Filamin C
GC
Gastric cancer
GDNF
glial cell derived neurotrophic factor
GI endoscopy
gastrointestinal endoscopy
GPX3
Glutathione peroxidase 3 (plasma)
GRIK2
Glutamate receptor, ionotropic, kainate 2
GSTP1
Glutathione S-transferase pi 1
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HAI-2/SPINT2
Serine peptidase inhibitor, Kunitz type, 2
hDAB2IP
DAB2 interacting protein
HGFA
hepatocyte growth factor activator
HLTF
Helicase-like transcription factor
hMLH1
mutL homolog 1
HOXA1
Homeobox A1
HOXA10
Homeobox A10
HoxD10
Homeobox D10
H. pylori
Helicobacter pylori
HRASLS
HRAS-like suppressor
IGF-1
Insulin-like growth factor 1 (somatomedin C)
IGF-1R
Insulin-like growth factor I receptor
IGFBP3
Insulin-like growth factor binding protein 3
IL-1β
Interleukin 1, beta
ITGA4
Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KL
Klotho
KRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
LMP2A
latent membrane protein
LOX
Lysyl oxidase
LRP1B
Low density lipoprotein receptor-related protein 1B
MAPK
RAS/RAF/MEK/ERK
MBPs
Methyl-CpG binding proteins
MDS
myelodysplastic syndromes
MINT25
Matrix metallopeptidase 24 (membrane-inserted)
MGMT
O-6-methylguanine-DNA methyltransferase
MLF1
Myeloid leukemia factor 1
MLL
Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
LL3
Myeloid/lymphoid or mixed-lineage leukemia 3
MMR
DNA mismatch repair
MSI
Microsatellite instability
MSP
Methylation-specific PCR
NDRG2
NDRG family member 2
Notch 1
Notch 1
NPR1
Natriuretic peptide receptor A/guanylate cyclase A
NR3C1
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
p15
Cyclin-dependent kinase inhibitor 2B
p16
Cyclin-dependent kinase inhibitor 2A
p21
Cyclin-dependent kinase inhibitor 1A
p27
Cyclin-dependent kinase inhibitor 1B
p53
tumor protein p53
p73
tumor protein p73
PCDH10
Protocadherin 10
PCDH17
Protocadherin 17
PI3K/Akt
phosphoinositide 3-kinase (PI3K)/Akt
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRDM5
PR domain containing 5
PTCH1
Patched 1
Q-MSP
Quantitative methylation-specific PCR
RARRES1
Retinoic acid receptor responder (tazarotene induced) 1
RARß
Retinoic acid receptor, beta
RASSF1A
Ras association (RalGDS/AF-6) domain family member 1
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
Rb
retinoblastoma
RBP1
Retinol binding protein 1, cellular
RKIP
Phosphatidylethanolamine binding protein 1
RORA
RAR-related orphan receptor A
ROS
reactive oxygen species
RUNX3
Runt-related transcription factor 3
SAM
S-adenosylmethionine
SFRP2
Secreted frizzled-related protein 2
SFRP5
Secreted frizzled-related protein 5
SHP1
Protein tyrosine phosphatase, non-receptor type 6
SOCS-1
Suppressor of cytokine signaling 1
STAT3
signal transducer and activator of transcription-3
SYK
Spleen tyrosine kinase
TCF4
Transcription factor 4
TET
ten-eleven translocation
TFPI2
Tissue factor pathway inhibitor 2
TGF-β
transforming growth factor-β
TIMP3
TIMP metallopeptidase inhibitor 3
TP73
Tumor protein p73
TSP1
Thrombospondin 1
TNM
Tumor Node Metastasis
ZIC1
Zinc finger protein of the cerebellum 1
ZNF545
ZFP82 zinc finger protein
Keywords
Gastric cancer
Epigenetics
Gene methylation
Biomarkers
Clinical outcomes
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Copyright © 2013 The Authors. Published by Elsevier B.V.