Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery and Radiotherapy for Early Breast Cancer: Results From a Large Series With Long-Term Follow-Up: Kunkler IH, on behalf of the Edinburgh Breast Group (Western General Hosp, Edinburgh, UK) Int J Radiat Oncol Biol Phys 83:829-838, 2012§

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Purpose

To investigate conventional prognostic factors for ipsilateral breast tumor recurrence (IBTR), distant metastasis (DM), and survival after breast-conserving therapy (BCT) in screen-detected and symptomatic cases on surveillance up to 25 years.

Patients and Methods

A total of 1812 consecutive patients in three cohorts (1981–1989, 1990–1992, and 1993–1998) with T12N01M0 invasive breast cancer were treated with BCT (median follow-up, 14 years). Tumor type and grade were reviewed by a single pathologist. Hormone receptor

Commentary

Breast cancer screening in the general population of women without known factors that place them at increased risk remains controversial. Despite decades of research, whether to screen, how often to screen, what age groups to screen, and the benefits compared with the risks of screening remain controversial. In this context, this study by Kunkler and colleagues provides additional data that are timely and constructive for the ongoing debate.

The data from this population-based screening program

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