Elsevier

Brain Research

Volume 1062, Issues 1–2, 16 November 2005, Pages 175-178
Brain Research

Short Communication
Trace amines reduce GABAB receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta

https://doi.org/10.1016/j.brainres.2005.09.009Get rights and content

Abstract

Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and β-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABAB-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.

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Acknowledgments

This work was supported by FIRB grants (RBNE01WY7P_010 and RBNE017555_006) to N.B.M.

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