Soluble epoxide hydrolase inhibitors of indolinone alkaloids and phenolic derivatives from Cimicifuga dahurica (Turcz.) Maxim.
Graphical abstract
Section snippets
Conclusions
This study identified the structures of two new indolinone alkaloid derivatives (5 and 6) and five related constituents (1–4 and 7) from C. dahurica using spectroscopic data analysis and chemical methods. Seven compounds from this plant exhibited sEH inhibitory activity, with IC50 values ranging from 0.8 ± 0.0 to 2.8 ± 0.4 μM. The results of kinetic analysis confirmed that compounds 1, 3, and 7 are mixed-type inhibitors, compound 2 is a non-competitive inhibitor, and compounds 4–6 are competitive
Acknowledgments
This study was supported by the Priority Research Center Program (2009-0093815) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology, Republic of Korea.
References (33)
- et al.
Prostaglandins Other Lipid Mediat
(2007) - et al.
Prog Lipid Res
(2005) - et al.
Biochem Syst Ecol
(1998) - et al.
Mol Cells
(2004) - et al.
Food Chem
(2007) - et al.
Biochem Syst Ecol
(2007) - et al.
Tetrahedron Lett
(2011) - et al.
Bioorg Med Chem
(2016) - et al.
J Histochem Cytochem
(2004) - et al.
Nat Rev Drug Discov
(2009)
Am J Physiol Cell Physiol
J Med Chem
Science
Hypertension
J Agric Food Chem
Proc Natl Acad Sci USA
Cited by (20)
A review of the genus Actaea L.: ethnomedical uses, phytochemical and pharmacological properties
2023, Journal of Herbal MedicineTwo new chemical constituents from the rhizomes of Actaea dahurica
2022, Natural Product ResearchSoluble epoxide hydrolase inhibitors from Docynia indica (Wall.) Decne.
2021, Natural Product ResearchPhenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica
2019, FitoterapiaCitation Excerpt :In traditional Chinese medicine, dried rhizomes of C. dahurica known as “Sheng Ma” are used as a heat-clearing and detoxifying agent for the treatment of toothache, abscess of throat, mouth ulcer and so forth [2]. Previous phytochemical studies on C. dahurica have led to discovery of triterpenoid saponins [3–5], indolinone alkaloids [6,7], phenolic acids [8], lignans [9], phenolic amides and their glycosides [10]. Pharmacological researches on C. dahurica showed its anti-tumor [11–13], anti-inflammatory [14,15], and neuro-protective [16,17] activities.
Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics
2018, Pharmacology and TherapeuticsCitation Excerpt :The search for therapeutics in nature that could alter epoxy-fatty acid levels has recently intensified. Plant-derived sEH inhibitors have recently been identified from Cimicifuga dahurica roots and from plants in the order Brassicales (Kitamura, Morisseau, Harris, Inceoglu, & Hammock, 2017; Thao, Luyen, Lee, Kim, & Kim, 2017). These plant-derived sEH inhibitors have not been tested for favorable renal and cardiovascular actions.