Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
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References and notes (43)
Circulation
(2001)- et al.
Am. J. Cardiol.
(2008) J. Lipid Res.
(1993)et al.Arterioscler. Thromb. Vasc. Biol.
(2003)- et al.
Curr. Opin. Drug Discovery Dev.
(2001)et al.Annu. Rep. Med. Chem.
(2000) - et al.
Lipid Res.
(1994) - et al.
J. Biol. Chem.
(1998) - et al.
Nature
(2000)et al.J. Med. Chem.
(2000) - et al.
Atherosclerosis
(2002) - et al.
J. Med. Chem.
(2011)et al.Engl. J. Med.
(2010)et al.J. Amer. Med. Assoc.
(2011)et al.Lancet
(2011)
Tetrahedron
(2012)
Arterioscler. Thromb. Vasc. Biol.
(1999)
N. Engl J. Med.
(1995)
et al.JAMA
(1998)
(d)Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin... et al.Lancet
(2003)
et al.Engl. J. Med.
(2004)
Engl. J. Med.
(1976)
et al.Am. J. Med.
(1977)
et al.J. Am. Med. Assoc.
(1986)
Am. J. Cardiol.
(1995)
et al.Atherosclerosis
(2000)
JAMA
(2001)
JAMA
(1988)
Am. J. Med.
(1994)
Curr. Med. Res. Opin.
(2004)
Eur. Heart J. Suppl.
(2005)
et al.Annu. Rev. Pharmacol. Toxicol.
(2008)
J. Am. Coll. Cardiol.
(2005)
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