Eudistomidins H–K, new β-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus

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Abstract

Four new β-carboline alkaloids, eudistomidins H–K (14), were isolated from an Okinawan marine tunicate Eudistoma glaucus and the structures of 14 were elucidated on the basis of spectroscopic data. Eudistomidins H (1) and I (2) were new β-carboline alkaloids possessing a unique fused-tetracyclic ring system consisting of a tetrahydro β-carboline ring and a hexahydropyrimidine ring. Eudistomidin J (3) showed relatively potent cytotoxicity against murine leukemia cells P388 and L1210, and human epidermoid carcinoma cells KB in vitro.

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Acknowledgments

We thank Mr. Z. Nagahama for his help with tunicate collection and Ms. S. Oka, Center for Instrumental Analysis, Hokkaido University, for measurements of ESIMS. This work was supported by Grant-in-Aid for Science Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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