Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

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Abstract

Ten phenolic compounds (110) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Graphical abstract

Ten phenolic compounds (110) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

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Acknowledgments

This work was supported by VAST and partly by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors are grateful to Institute of Chemistry, VAST and KBSI for provision of spectroscopic instrument.

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    These authors contributed equally to this work.

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