Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity
Graphical abstract
Compound 5c has shown mean GI50: 9.33 ± 1.3 μM against NCIH460, HCT116 and U251 cell lines and IC50: 33.67 μM against HDAC8. It also inhibited HL60 human promyelocytic leukemia cell line due to the presence of pharmacophoric features of RR inhibitor.
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Acknowledgments
The author was grateful to the Head, Sophisticated Analytical Instrument Facility (SAIF), CDRI Lucknow, India, for providing spectral data and the first author was thankful to UGC for Junior Research Fellowship.
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