Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species

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Abstract

Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines.

Graphical abstract

Mixed ferrocene/ruthenium bioorganometallics.

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Acknowledgments

K.K. is grateful to the Alexander von Humboldt-Stiftung for a research fellowship at the group of Professor Dr. R. F. Winter, University of Regensburg. Financial support within the research unit FOR630 by DFG (Deutsche Forschungsgemeinschaft) and the technical assistance of Silke Bergemann and Heike Scheffler are gratefully acknowledged.

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