Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay
Graphical abstract
A versatile synthesis and SAR study of the sulfonamide scaffold are reported.
Section snippets
Acknowledgments
This work was supported by the US National Institutes of Health 1 U54 HG003918-02 and 1R03MH076499-01, and encouraged by Professor Dennis Liotta (Emory University).
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