Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands
Graphical abstract
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their thyroid hormone receptor selectivity has been evaluated. 3-[3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.
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Acknowledgments
Authors are thankful to Dr. Brijesh Kumar Srivastava, Ms. Rina Soni, and Mr. Sidhartha S. Kar for their help in the preparation of the manuscript, management of the Zydus Group for encouragement and the analytical department for the support.
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