Macrocyclic ureas as potent and selective Chk1 inhibitors: An improved synthesis, kinome profiling, structure–activity relationships, and preliminary pharmacokinetics
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Acknowledgments
The authors thank Drs. Zhenping Tian and Daniel Plata for scaling up a pyrazine-containing intermediate, Drs. Le Wang, Kent D. Stewart, and Chang Park for helpful discussion on the design of macrocyclic kinase inhibitors. The authors also thank the Department of Structural Chemistry for measuring NMR and MS spectra, the High-Through-Put Purification Group for analytical LC–MS.
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