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doi:10.1016/j.bmcl.2006.03.079 
Copyright © 2006 Elsevier Ltd All rights reserved.
Synthesis and antibacterial activity of nocathiacin I analogues
B. Narasimhulu Naidu
, 
, Margaret E. Sorenson, John D. Matiskella, Wenying Li, Justin B. Sausker, Yunhui Zhang, Timothy P. Connolly, Kin S. Lam, Joanne J. Bronson, Michael J. Pucci, Hyekyung Yang and Yasutsugu Ueda
Received 5 March 2006;
revised 23 March 2006;
accepted 24 March 2006.
Available online 18 April 2006.
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Abstract
Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility.
Keywords: Nocathiacin I; Antibacterial activity
