Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–activity relationships
Graphical abstract
Novel quinazolinethiones and quinazolinediones are reported which exhibit IMPDH II inhibitory activity.
References and notes (15)
- et al.
J. Biol. Chem.
(1988) - et al.
J. Biol. Chem.
(1990) - et al.
J. Mol. Biol.
(1995) - et al.
Nature
(1975) - et al.
Curr. Med. Chem.
(1999)
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