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doi:10.1016/j.biopsycho.2008.05.004

Relationship between trait anxiety, prefrontal cortex, and attention bias to angry faces in children and adolescents

Eva H. Telzer^a^,^,, Karin Mogg^b, Brendan P. Bradley^b, Xiaoqin Mai^c, Monique Ernst^d, Daniel S. Pine^d and Christopher S. Monk^e^,^f

^aDepartment of Psychology, University of California, Los Angeles, CA, United States ^bSchool of Psychology, University of Southampton, Southampton, United Kingdom ^cCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, United States ^dMood and Anxiety Disorders Program, NIMH, National Institutes of Health (NIH), DHHS, Bethesda, MD, United States ^eDepartment of Psychology, Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, United States ^fDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, United States

Received 2 October 2007;

accepted 13 May 2008.

Available online 29 May 2008.

References and further reading may be available for this article. To view references and further reading you must purchase this article.

Abstract

Using event-related functional magnetic resonance imaging (fMRI) with a visual-probe task that assesses attention to threat, we investigated the cognitive and neurophysiological correlates of trait anxiety in youth. During fMRI acquisition, 16 healthy children and adolescents viewed angry-neutral face pairs and responded to a probe that was on the same (angry-congruent) or opposite (angry-incongruent) side as the angry face. Attention bias scores were calculated by subtracting participants’ mean reaction time for angry-congruent trials from angry-incongruent trials. Trait anxiety was positively associated with attention bias towards angry faces. Neurophysiologically, trait anxiety was positively associated with right dorsolateral prefrontal cortex (PFC) activation on a contrast of trials that reflect the attention bias for angry faces (i.e. angry-incongruent versus angry-congruent trials). Trait anxiety was also positively associated with right ventrolateral PFC activation on trials with face stimuli (vesus baseline), irrespective of their emotional content.

Keywords: Functional MRI; Trait anxiety; Prefrontal cortex; Attention

Article Outline

1. Method 1.1. Participants 1.2. Measures 1.2.1. Trait anxiety 1.2.2. Visual-probe task 1.3. Analyses 1.3.1. Behavioral data analysis 1.3.2. fMRI analysis
2. Results 2.1. Behavioral results 2.2. fMRI results
3. Discussion
Acknowledgements
References

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Biological Psychology
Article in Press, Corrected Proof - Note to users

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