PerspectiveNon-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
Graphical abstract
Abbreviations
NSAID
Non-steroidal anti-inflammatory drug
PGHS
Prostaglandin-endoperoxide synthase
PG
Prostaglandin
FDA
US Food and Drug Administration
IC
Inhibitory concentration
P450
Cytochromes P450
PLA
Phospholipase
Tx
Thromboxane
LTE
Leukotriene
MOS
Mitochondrial oxidative stress
ETC
Electron transport chain
O2.-
Superoxide
CVD
Cardiovascular disease
TNF-α
Tumor necrosis factor-alpha
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells
ICAM-1
Intercellular adhesion molecule 1
MAPK
Mitogen activated protein kinase
PKC
Protein kinase C
DRP1
Dynamin-related protein 1
LPS
Lipopolysaccharide
HMGB1
High mobility group box 1
DAMP
Damage associated molecular pattern
MEDAL
Multinational Etoricoxib and Diclofenac Arthritis Long-term trial
GI
Gastrointestinal
MI
Myocardial infarction
HF
Heart failure
VIGOR
Vioxx Gastrointestinal Outcomes Research
APPROVe
Adenomatous Polyp PRevention On Vioxx trial
PRECISION
Prospective Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen
NANSAIDs
Non aspirin NSAIDs
ADMA
Asymmetric dimethyl arginine
eNOS
Endothelial nitric oxide synthase
CKD
Chronic kidney disease
AKI
Acute kidney injury
GFR
Glomerular filtration rate
PPAR
Peroxisome proliferator-activated receptor
CRESCENT
Celecoxib Rofecoxib Efficiency and Safety in Cormorbidities Evaluation Trial
ICH
Intracerebral haemorrhage
AERD
Aspirin-exacerbated respiratory disease
CAP
Community Acquired Pneumonia
Cys-LTEs
Cysteinyl leukotrienes
Keywords
NSAID
Cyclooxygenase
Prostaglandin
Inflammation
Mitochondria
Organ damage
Apoptosis
Gastropathy
Cited by (0)
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Present address: National Institute of Biomedical Genomics, P.O.: N.S.S., Kalyani, West Bengal 741251 India
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