Short communicationFurther validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: Restoration of bilateral food retrieval by dopamine receptor agonism
Section snippets
Acknowledgement
We thank Mr. Ambrose O’Halloran for constructing the corridor apparatus.
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PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats
2021, Neurobiology of DiseaseCitation Excerpt :In addition, the PFF rats had less retrieved-eaten and more retrieved-fallen pellets suggesting sensorimotor problems. While the 6-OHDA PD model shows signs of neglect in the corridor test (Fitzsimmons et al., 2006), we did not find this in the PFF rats, despite the partial denervation in striatum. This absence of hemispatial neglect is in agreement with our previous data in a non-human primate PD model based on unilateral a-syn overexpression via rAAV, which showed a similar level of nigral neuronal death to the current model (Eslamboli et al., 2007).
Differential pattern of motor impairments in neurotoxic, environmental and inflammation-driven rat models of Parkinson's disease
2016, Behavioural Brain ResearchCitation Excerpt :This was completed on both the ipsilateral and contralateral sides of the rat’s body. The Corridor Test of contralateral neglect was completed as previously described [7,11]. Briefly, the rat was placed into a long corridor and was allowed to freely retrieve CocoPops® from pots plated at intervals on the left and the right-hand sides of the corridor.
Saxagliptin: A novel antiparkinsonian approach
2015, NeuropharmacologyThe behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats
2013, Behavioural Brain ResearchCitation Excerpt :The osmotic minipumps (Alzet®, model 2ML4) for delivery of rotenone or vehicle were also subcutaneously implanted (through a small incision on the back of the rat) under isofluorane anaesthesia (5% in O2 for induction and 2% in O2 for maintenance) 13 weeks after viral infusion. The Corridor Test of contralateral neglect has been described in more detail elsewhere [24,25]. In brief, hungry rats (deprived of food overnight) were placed into a long, narrow alleyway (150 cm) and were free to retrieve food reward (crisped rice cereal (CocoPops®)) from pots on the left and right sides.