Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate
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Graphical abstract
Abbreviations
AA
arachidonic acid
AFM
atomic force microscopy
BAT
brown adipose tissue
BSA
albumin from bovine serum
CL
cardiolipin from bovine heart
DOPC
1,2-Dioleoyl-sn-glycero-3-phosphocholine
α-CD
alpha-cyclodextrin
DOPE
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
DTT
dithiothreitol
EGTA
ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid
EPL
E. coli polar lipid extract
FFA
free fatty acid
IMM
inner mitochondrial membrane
MES
2-(N-morpholino) ethanesulfonic acid
PN
purine nucleotide
ROS
reactive oxygen species
TREC
simultaneous topography and recognition imaging by AFM
Tris
tris(hydroxymethyl)amino-methane
UCP
uncoupling proteins
Keywords
Mitochondrial uncoupling proteins
Conductance of planar bilayer membrane
Purine nucleotide binding site
Atomic force microscopy
Molecular mechanism of protein inhibition
Arachidonic acid
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Current address: Institute of Life Science, University Catholiqué de Louvain, Louvain-la-Neuve, Belgium.
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