Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1807, Issue 11, November 2011, Pages 1432-1443
ReviewSDH mutations in cancer
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Highlights
► Germline loss-of-function mutations in any of the SDH genes cause HPGL/PCC syndrome. ► Germline loss-of-function mutations in SDHAF2 gene cause HPGL/PCC syndrome. ► SDH deficiency induces pseudohypoxia. ► Succinate accumulation might inhibits α-ketoglutarate-dependent dioxygenases.
Keywords
Succinate dehydrogenase
Mitochondrial tumor suppressor genes
Hereditary paraganglioma-phaechromocytoma syndrome
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