Original articleGeneral thoracicMaximal Standardized Uptake Value on FDG-PET Is Correlated With Cyclooxygenase-2 Expression in Patients With Lung Adenocarcinoma
Section snippets
Study Population
Sixty patients with lung adenocarcinomas measuring less than 3 cm in diameter who underwent surgical resection (lobectomy or segmentectomy) with systematic lymph node dissection at Kawasaki Medical School Hospital between 2007 and 2009 were enrolled in this study. None of the patients had received either radiotherapy or chemotherapy before the surgery. The histologic diagnosis of the tumors was based on the criteria of the World Health Organization, and the TNM stage was determined according to
Clinical Characteristics
The characteristics of the patients are summarized in Table 2. The patients ranged in age from 46 to 83 years (mean, 66.8 years). There were 29 men and 31 women. The median value of the SUVmax of all the tumors was 5.9 ± 5.2 (range, 0 to 18.1). No statistically significant association was observed between the SUVmax of primary tumors and the age, sex, or smoking status of the patients. A statistically significant correlation was observed between the SUVmax and the degree of tumor
Comment
The SUV measured on FDG-PET is a semiquantitative value that indicates the degree of glucose uptake in a lesion. The SUVmax of primary lung nodules has been reported to be helpful in distinguishing between malignant and benign tumors, based on the relatively higher values in malignant tumors [27]. We speculated that tumors showing higher SUVmax might be more aggressive and have a higher proliferation potential. We examined this hypothesis by studying the correlation between the SUVmax and the
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Invited commentary
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