Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome
Section snippets
Design and subjects
This cross-sectional study was performed on the employees of a single large construction company, all of whom underwent a routine annual health checkup between May and July 2004. In addition to the routine tests, measurements of the plasma levels of CRP and lipOX were also conducted in the subjects enrolled for this study. The routine annual health checkup included evaluation of the atherosclerotic risk factors {body mass index, serum levels of triglycerides (TG), high-density lipoprotein
Results
The quartile ranges for the serum levels of ALT and GGT were as follows—ALT (U/L): 6–16, 17–21, 22–30, and 31–231; GGT (U/L): 6–23, 24–35, 36–58, and 59–266. Table 1 shows the clinical characteristics of the subjects with and without elevated serum ALT and of those with and without elevated serum GGT. Ethnic differences have been reported in relation to the plasma level of CRP [22]. The mean value of CRP in the subjects in this study was consistent with that reported from other studies
Discussion
The present study was the first to examine whether elevated serum ALT and/or serum GGT might be individually related to increased plasma levels of CRP and lipOX, independent of their relationship with the MetS. In the present study, the odds ratios for the presence of elevated serum ALT and/or serum GGT increased as the number of components of the MetS present in the subjects increased. However, a GLM analysis demonstrated that elevated serum ALT and/or elevated serum GGT were individually
Acknowledgement
This study was supported in part by a Grant-in-Aid from the Japanese Atherosclerosis Prevention Fund, awarded to Prof. Akira Yamashina.
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