Case ReportGhost cell odontogenic carcinoma arising in calcifying odontogenic cyst
Section snippets
Case report
A 17-year-old woman with a maxillary mass, discovered by the computed tomography (CT) in other hospital, was admitted to our hospital. She had a history of odontogenic cystic lesion that had been repeatedly treated with a series of local resections with subsequent recurrences. The first surgical excision was performed 5 years before. The pathologic diagnosis was CCOT. Three years later, the tumor recurred as a cystic tumor, and a tumor excision was performed next year. This time (another 1 year
Pathologic findings
In the specimen of the first surgical excision performed 5 years ago, tumor was macroscopically cystic and surrounding a corona dentis. Microscopically, the cyst wall was mainly composed of reduced enamel epithelium with a part of dense small atypical cell proliferation and a few ghost cells. Mitosis was less than 1 per high-power field. Immunohistochemical staining showed that the Ki-67 index was 1% to 6% (mean, 5.3%). Only less than 5% of tumor cells were faintly positive for p53 (Fig. 1).
Discussion
Ghost cell odontogenic carcinoma is a rare malignant tumor. To our best knowledge, there have been only 27 cases reported so far [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]. It is believed that ghost cell odontogenic carcinoma may develop as a de novo tumor or arise from a previously existed COC (CCOT or DGCT) [20]. Some of the previously reported cases are described as long-term persistent swelling of maxilla followed by the rapid
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Treatment challenges of persistent ghost cell odontogenic carcinoma: a case report and literature review
2023, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyGhost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor with next-generation sequencing cancer panel analysis: A case report
2022, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :In our case, the boundary between the GCOC and DGCT components was clear in the resected specimen. Cell atypia, mitosis, Ki-67, and p53 immunohistochemistry distinguish these lesions.7 In general, the Ki-67 labeling index of DGCT is <5%.1
Ghost cell odontogenic carcinoma transformed from dentinogenic ghost cell tumor of the maxilla after recurrences
2017, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :The characteristic of GCOC is aggressive and destructive behavior. Only 40 cases of GCOC have been reported in the literature to date, including this case [2–31]. The results of a systematic analysis of the reported cases of GCOC are summarized in Table 1.
Integrative genomic analysis of ghost cell odontogenic carcinoma
2015, Oral OncologyCalcifying cystic odontogenic tumor and adenomatoid odontogenic tumor: Radiographic evaluation
2012, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :The presence of root resorption supports the suggested aggressive nature of CCOTs.12 In addition, a few recurrences5 and malignant transformation of a preexisting CCOTs25-28 have been described; therefore, long-term follow-up of CCOTs is recommended.12 In our series, AOTs were associated with tooth displacement in 75% of cases and root resorption in 12.5% of cases.