CardiomyopathyRelation of Cardiac Dysfunction to Rhythm Abnormalities in Patients With Duchenne or Becker Muscular Dystrophies
Section snippets
Methods
A retrospective chart review of all patients with DMD or BMD at Texas Children's Hospital (Houston, Texas) was performed with approval from the internal review board. Patients with both 24-hour Holter monitoring and echocardiography were included. Patients with DMD or BMD generally have a slow decrease in cardiac function, but can also demonstrate acute decrease with subsequent improvement in function, particularly during times of acute respiratory illness. To accommodate the fluctuating
Results
A retrospective chart review was conducted on 266 patients with DMD and 56 patients with BMD at Texas Children's Hospital based on data from 2008 to 2015. Of these patients, all of whom were males, 91 patients with DMD and 21 patients with BMD had 24-hour Holter recordings with corresponding echocardiography that met study criteria. From these patients, a total of 237 and 64 Holter studies with corresponding echocardiography were reviewed and summarized. At the time of Holter monitoring,
Discussion
The association between cardiac dysfunction and arrhythmias in the muscular dystrophies has generally been assumed; however, this is the first study to formally evaluate and demonstrate a statistically significant association between progressive cardiac dysfunction and cardiac arrhythmias in patients with DMD or BMD. Among patients with DMD, we found a statistically significant association between cardiac dysfunction and incidence of any arrhythmia as well as clinically significant arrhythmias
Acknowledgment
The authors thank Melissa Smith, RN and Melissa Domino, RN (Texas Children's Hospital, Houston, Texas) for their assistance with data collection and Shaine Morris, MD, MPH (Texas Children's Hospital, Houston, Texas) for advice on statistical analysis.
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