Coronary artery diseaseUsefulness of Desirable Lifestyle Factors to Attenuate the Risk of Heart Failure Among Offspring Whose Parents had Myocardial Infarction Before Age 55 Years
Section snippets
Methods
The Physicians' Health Study (PHS) I is a completed randomized, double-blind, placebo-controlled trial designed to study the effects of low-dose aspirin and β-carotene on cardiovascular disease and cancer in United States male physicians. In 1997, a second randomized trial, PHS II, was started and included 7,641 physicians from PHS I along with 7,000 new physicians. Detailed descriptions of PHS I and PHS II have been published elsewhere.1, 2 Participants from PHS I, including the 7,641 subjects
Results
Among 20,060 participants in PHS I, the mean age at 12 months after randomization was 55 ± 9.5 years. Table 1 lists baseline characteristics of the study participants. Although 94% of the subjects did not report parental histories of premature MI, 6% of the participants had ≥1 parent who had an MI before the age of 55 years. In addition, 60% of the subjects had good lifestyle scores. Subjects with parental histories of premature MI were noted to be younger than those with no parental histories
Discussion
Our findings demonstrate that in the presence of parental history of premature MI, adherence to healthful lifestyle factors was associated with a lower risk for HF with antecedent MI. Our data suggest that the influence of healthful lifestyle factors on this association might be stronger at younger compared to older ages.
Genetic factors have been demonstrated to play an important role in the development of HF.6, 7 Several important HF predictors have also been shown to have a strong genetic
Acknowledgment
We are indebted to the participants in the PHS for their outstanding commitment and cooperation and to the entire PHS staff for their expert and unfailing assistance.
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Cited by (8)
Lifestyle Indices and Cardiovascular Disease Risk: A Meta-analysis
2018, American Journal of Preventive MedicineCitation Excerpt :This result may relate to the present meta-analysis indicating that a high proportion of mortality might be explained by incident CVD. Moreover, the present results are in accordance with other studies that could not be included in the present analyses because of the lack of an appropriate risk estimate for the whole study population: Having a low healthy lifestyle score (score zero to two) among those with a parental history of premature MI was associated with a MI risk of 4.60 (95% CI=2.55, 8.30) compared with participants with a high lifestyle score (score three to four) and without parental history of premature MI.37 Moreover, a study pooling three large cohort studies showed that adherence to a healthy lifestyle decreases the risk of coronary events and subclinical burden of coronary artery disease in all genetic risk categories suggesting that a healthy lifestyle is advantageous for all individuals even with a high genetic risk of CHD.38
Dietary patterns and components to prevent and treat heart failure: a comprehensive review of human studies
2019, Nutrition Research ReviewsFamily History of Modifiable Risk Factors and Association With Future Cardiovascular Disease
2023, Journal of the American Heart AssociationImportance of healthy lifestyle factors and ideal cardiovascular health metrics for risk of heart failure in Chinese adults
2022, International Journal of Epidemiology
This study was supported by Grants R01 HL092946 and HL092946-S1 (to Dr. Djoussé) from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. The Physicians' Health Study is supported by Grants CA-34944, CA-40360, and CA-097193 from the National Cancer Institute and Grants HL-26490 and HL-34595 from the National Heart, Lung, and Blood Institute.