Original ResearchClinical Significance of Fibrinogen Degradation Product Among Traumatized Patients
Section snippets
Methods
The protocol of this retrospective study was approved by the review board of Numazu City Hospital and Juntendo Shizuoka Hospital, and all examinations were conducted in accordance with the standards of good clinical practice and the Helsinki Declaration.
Numazu City Hospital, which is a hospital with 426 beds and a medical emergency center in eastern Shizuoka Prefecture located near Tokyo, serves a population of approximately 190,000. The helicopter parks at Juntendo Shizuoka Hospital, and the
Results
During the investigation period, a total of 189 patients were transported to Numazu City Hospital by the DH. Among these patients, 37 did not have their FDP or D-dimer levels evaluated. After excluding these patients, a total of 151 patients were enrolled as subjects. There were 135 patients in the survival group and 16 in the fatal group. Among these 151 patients, 44 had their D-dimer levels assessed but not their FDP levels; therefore, the FDP level was calculated based on the D-dimer level.
Discussion
This is the first study to show that among trauma patients transported by the DH the level of consciousness, blood pressure, ISS, FDP level, base excess, and presence of head injury were associated with fatality. In addition, the FDP level at arrival had a positive correlation with anatomic traumatic severity.
Previous reports have revealed that FDP levels increase because of trauma and are correlated with the severity of the trauma.4, 7, 9 Concerning the mechanism of the positive correlation
Conclusion
Therefore, the FDP level may be a useful biochemical parameter for the initial evaluation of the severity of trauma, even in blunt trauma patients without head injury or with stable vital signs.
Acknowledgment
Supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT)-Supported Program for the Strategic Research Foundation at Private Universities, 2015-2019 concerning [The constitution of total researching system for comprehensive disaster, medical management, corresponding to wide-scale disaster].
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2021, Clinica Chimica ActaCitation Excerpt :Previous reports have revealed that FDP and DD are easily measured and commonly considered the best available laboratory markers of coagulation activation and those levels have been found to correlate with the extent of thrombosis[38]. In addition, some studies have found that the levels of FDP increase after trauma are correlated with the severity of the trauma[39]. The elevated levels of FDP in trauma patients in our study were consistent with the findings of previous studies.
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