In this study, we use the spectral collocation method using Chebyshev polynomials for spatial derivatives and fourth order Runge–Kutta method for time integration to solve the generalized Burger’s–Huxley equation (GBHE). To reduce round-off error in spectral collocation (pseudospectral) method we use preconditioning. Firstly, theory of application of Chebyshev spectral collocation method with preconditioning (CSCMP) and domain decomposition on the generalized Burger’s–Huxley equation presented. This method yields a system of ordinary differential algebric equations (DAEs). Secondly, we use fourth order Runge–Kutta formula for the numerical integration of the system of DAEs. The numerical results obtained by this way have been compared with the exact solution to show the efficiency of the method.