Original articleLeukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model
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Keywords
Asthma
Cysteinyl leukotrienes
Double-stranded RNA
Leukotriene receptor antagonist
Virus
Abbreviations
Ach
acetylcholine
AHR
airway hyperresponsiveness
ASM
airway smooth muscle
BAL
bronchoalveolar lavage
BALF
bronchoalveolar lavage fluid
CCL
Chemokine (C-C Motif) Ligand
CXCL
Chemokine (C-X-C Motif) Ligand
cysLTs
cysteinyl leukotrienes
cysLT1R
cysteinyl leukotriene receptor 1
dsRNA
double-stranded RNA
ICS
inhaled corticosteroids
ILC2s
type 2 innate lymphoid cells
i.n.
intranasally
i.p.
intraperitoneally
KC
Keratinocyte chemoattractant
LTC4S
leukotriene C4 synthase
LTD4
leukotriene D4
LTRA
leukotriene receptor antagonist
MIP-1α
Macrophage inflammatory protein-1 alpha
OVA
ovalbumin
PBS
phosphate buffered saline
poly I:C
polyinosinic–polycytidylic acid
PSL
prednisolone
Raw
airway resistance
RSV
respiratory syncytial virus
TSLP
thymic stromal lymphopoietin
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