Late-breaking abstract
LB2: Prospective study of the association between sleep disordered breathing and hypertensive disorders of pregnancy and gestational diabetes

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Objective

To determine whether sleep disordered breathing (SDB) during pregnancy is a risk factor for adverse pregnancy outcomes.

Study Design

3702 women were recruited to undergo objective, overnight in-home assessments of SDB in early pregnancy (6-15 weeks) and again in mid-pregnancy (22-31 weeks). Assessments were scored by a central Sleep Reading Center. SDB was defined using an Apnea Hypopnea Index (AHI) cut-off of ≥ 5; an AHI of 5–<15 is mild SDB, and ≥15 moderate-severe SDB. The primary outcome measures were hypertensive disorders of pregnancy (mild, severe, or superimposed preeclampsia; eclampsia; or antepartum gestational

Results

Adequate data were obtained in early pregnancy on 3261 women (88.1% of studies attempted) and in mid-pregnancy on 2511 women (87.6% of studies attempted). The prevalence of SDB in early and mid-pregnancy was 3.3% and 8.1%, respectively. Outcome rates by SDB status are shown in the Table. SDB in mid-pregnancy was associated with hypertensive disorders of pregnancy (aOR 1.62; 95% CI 1.10, 2.39). SDB in early (aOR 3.62; 95% CI 2.01, 6.53) and mid-pregnancy (aOR 2.79, 95% CI 1.62, 4.81) was

Conclusion

SDB during pregnancy is associated with hypertensive disorders of pregnancy and GDM. Further research should help to establish whether screening for and treating SDB in pregnancy can lessen the risk of these outcomes.

  • 1/ Hypertensive disorder of pregnancy includes mild, severe, and superimposed preeclampsia and eclampsia, plus antepartum gestational hypertension.

  • 2/ Early and mid-pregnancy adjusted for age, BMI and chronic hypertension as determined in early pregnancy. Mid-pregnancy also adjusted

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