ResearchGeneticsAssociation of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers
Section snippets
Materials and Methods
Evaluation of early-preterm biomarker relationships was undertaken in 2 independent datasets; one set was used for model building (the “training” study set), and one set was used for model testing (the “testing” study set). The training study set included 345 early-preterm singleton cases (<30 weeks of gestation) and 1725 term singleton pregnancies (control subjects) with expected dates of delivery in September 2009 through December 2010. These cases and control subjects were drawn from 497,023
Results
Early-preterm cases and term control subjects in the training study set were mostly Hispanic (43.2% and 40.5%, respectively) and were between 18 and 34 years old (72.8% and 72.1%, respectively). Pregnancies that resulted in early-preterm birth were more likely than term control subjects to be black, regardless of early-preterm grouping (spontaneous labor, medically indicated, or combined; OR, 2.5 and 4.3; Table 1).
Cases in the training study set (with spontaneous or medically indicated preterm
Comment
This study explored population-level screening and clinical data from 2 separate population cohorts to investigate whether preterm birth (overall and by medically indicated and spontaneous labor subgroups) was associated with single and multiple biomarker abnormalities. This study showed increased risks for early-preterm birth when the first-trimester PAPP-A level was low and/or when second-trimester AFP and/or inhibin levels were high, irrespective of whether the preterm birth was spontaneous
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2019, Clinica Chimica ActaCitation Excerpt :Moreover, there is controversy about the association of abnormal concentrations of uE3 with unfavorable perinatal outcomes. For example, no correlation between elevated uE3 concentration and PTB was reported by Jelliffe-Pawlowski et al., however, Oslen et al. observed a direct linkage between high maternal serum uE3 concentrations and a higher incidence of PTB [10,11]. On the other hand, limited data have been published regarding the role of triple screen for Down syndrome in second-trimester as a predicting tool for pregnancy outcomes in Chinese pregnant women.
Funded in part by grants from the National Institutes of Health/National Heart, Lung and Blood Institute (RC2 HL101748) and the March of Dimes Prematurity Center, Stanford University School of Medicine, Stanford, CA.
The authors report no conflict of interest.
Cite this article as: Jelliffe-Pawlowski LL, Shaw GM, Currier RJ, et al. Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers. Am J Obstet Gynecol 2013;208:492.e1-11.